4-iodo-SAHA

Catalog #: 27205
Size: 50 mg
$110
MW: 390.2 Da
CAS Registry #: 1219807-87-0
Formula: C14H19IN2O3
Description:

4-iodo-SAHA is a hydrophobic derivative of SAHA, a class I and class II histone deacetylase (HDAC) inhibitor. Similar to SAHA, it demonstrates > 60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay at 1 µM.

Purity:

≥98% by HPLC

Biological Activity:
4-iodo-SAHA inhibits SKBR3 breast-derived and HT29 colon-derived cell line proliferation with EC50 values comparable to that of SAHA (1.1 µM and 0.95 µM versus 2.1 µM and 2 µM, respectively). It has 10 times the inhibition strength of U937 leukemia cell proliferation in comparison to SAHA (0.12 µM versus 1.2 µM, respectively).
Solubility:
Solubility in ethanol is 0.2 mg/ml and 30 mg/ml in DMSO and DMF. First, dissolve in DMSO then dilute with the aqueous buffer of choice.
Format:
A crystalline solid
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
Salmi-Smail, C., et al., J. Med. Chem. 2010; 53: 3038 – 3047.
Scientific Category:
HDAC
Product Type:
Inhibitor
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Product Datasheets

27205.pdf