3-Deazaneplanocin (DZNep)

Catalog #
27617-1
$450 *
Size: 5 mg
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Description

3-Deazaneplanocin was synthesized as an inhibitor of S-adenosylhomocysteine hydrolase. It is an analog of adenosine and inhibits S-adenosylhomocysteine hydrolase through competing with the substrate, adenosine. 

Synonyms
DZNep, 3-Deazaneplanocin A, NSC 617989, NSC617989, (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
Product Info
Storage and Usage
Citations
Purity

≥98% by HPLC

Target(s)
EZH2
Formula
C12H24N4O3
MW
262.26 Da
Solubility

insoluble in EtOH; ≥17.07 mg/mL in DMSO; ≥17.43 mg/mL in H2O

Biological Activity

3-deazaneplanocin A (DZNeP), an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.

CAS Registry #
102052-95-9
References
1. Fujiwara T, et al. J Biol Chem. 2014 Mar 21;289(12):8121-34.
2. Cui, B., et al. J Clin Endocrinol Metab. 2014 Jun;99(6):E962-70.
3. Cheng, L.L., et al. Clin Cancer Res. 2012 Aug 1;18(15):4201-12.
4. Nakagawa, S., et al. Oncol Rep. 2014 Feb;31(2):983-8.